Circulating HLA-DR(+)CD4(+) effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis

Chronic T cell activation is a hallmark of pulmonary tuberculosis (PTB). The mechanisms underpinning this important phenomenon are however, poorly elucidated, though known to rely on control of T effector cells (Teff) by regulatory T cells (Treg). Our studies show that circulating natural Treg cells...

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Detalles Bibliográficos
Autores principales: Ahmed, Asma, Adiga, Vasista, Nayak, Soumya, Uday Kumar, J. Anto Jesuraj, Dhar, Chirag, Sahoo, Pravat Nalini, Sundararaj, Bharath K., Souza, George D., Vyakarnam, Annapurna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166982/
https://www.ncbi.nlm.nih.gov/pubmed/30231065
http://dx.doi.org/10.1371/journal.ppat.1007289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166982/
https://www.ncbi.nlm.nih.gov/pubmed/30231065
http://dx.doi.org/10.1371/journal.ppat.1007289

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