Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

[Image: see text] Four HIV-1 protease (PR) inhibitors, clinical inhibitors lopinavir and tipranavir, and two investigational compounds 4 and 5, were studied for their effect on the structure and activity of PR with drug-resistant mutation L76V (PR(L76V)). Compound 5 exhibited the best K(i) value of...

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Detalles Bibliográficos
Autores principales: Wong-Sam, Andres, Wang, Yuan-Fang, Zhang, Ying, Ghosh, Arun K., Harrison, Robert W., Weber, Irene T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167001/
https://www.ncbi.nlm.nih.gov/pubmed/30288468
http://dx.doi.org/10.1021/acsomega.8b01683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167001/
https://www.ncbi.nlm.nih.gov/pubmed/30288468
http://dx.doi.org/10.1021/acsomega.8b01683

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