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KChIP3 coupled to Ca(2+) oscillations exerts a tonic brake on baseline mucin release in the colon

Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline release of mucin can exceed quantities released by stimulated secretion, yet...

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Detalles Bibliográficos
Autores principales: Cantero-Recasens, Gerard, Butnaru, Cristian M, Valverde, Miguel A, Naranjo, José R, Brouwers, Nathalie, Malhotra, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167051/
https://www.ncbi.nlm.nih.gov/pubmed/30272559
http://dx.doi.org/10.7554/eLife.39729