Structure of the NDH-2 – HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors

Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum. Many NDH-2 inhibitors have been identified, but rational drug development is impeded by the lack of information regarding their mode...

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Detalles Bibliográficos
Autores principales: Petri, Jessica, Shimaki, Yosuke, Jiao, Wanting, Bridges, Hannah R., Russell, Euan R., Parker, Emily J., Aragão, David, Cook, Gregory M., Nakatani, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167311/
https://www.ncbi.nlm.nih.gov/pubmed/29621505
http://dx.doi.org/10.1016/j.bbabio.2018.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167311/
https://www.ncbi.nlm.nih.gov/pubmed/29621505
http://dx.doi.org/10.1016/j.bbabio.2018.03.014

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