AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

Immune responses to inactivated vaccines against avian influenza are poor due in part to lack of immune memory. Adjuvants significantly increased virus neutralizing titers. We performed comprehensive analyses of polyclonal antibody responses following FDA-approved adjuvanted H5N1-A/Indonesia vaccine...

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Detalles Bibliográficos
Autores principales: Khurana, Surender, Coyle, Elizabeth M., Manischewitz, Jody, King, Lisa R., Gao, Jin, Germain, Ronald N., Schwartzberg, Pamela L., Tsang, John S., Golding, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167326/
https://www.ncbi.nlm.nih.gov/pubmed/30302282
http://dx.doi.org/10.1038/s41541-018-0076-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167326/
https://www.ncbi.nlm.nih.gov/pubmed/30302282
http://dx.doi.org/10.1038/s41541-018-0076-2

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