A flow platform for degradation-free CuAAC bioconjugation

The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation and Cu-contamination in bioconjugates limits biomedical utility. Here, we report a generic CuAAC flow platform for the rapid, robust, and br...

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Detalles Bibliográficos
Autores principales: Hatit, Marine Z. C., Reichenbach, Linus F., Tobin, John M., Vilela, Filipe, Burley, Glenn A., Watson, Allan J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167327/
https://www.ncbi.nlm.nih.gov/pubmed/30275543
http://dx.doi.org/10.1038/s41467-018-06551-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167327/
https://www.ncbi.nlm.nih.gov/pubmed/30275543
http://dx.doi.org/10.1038/s41467-018-06551-0

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