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A flow platform for degradation-free CuAAC bioconjugation
The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation and Cu-contamination in bioconjugates limits biomedical utility. Here, we report a generic CuAAC flow platform for the rapid, robust, and br...
Autores principales: | Hatit, Marine Z. C., Reichenbach, Linus F., Tobin, John M., Vilela, Filipe, Burley, Glenn A., Watson, Allan J. B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167327/ https://www.ncbi.nlm.nih.gov/pubmed/30275543 http://dx.doi.org/10.1038/s41467-018-06551-0 |
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