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Silencing of TGFβ signalling in microglia results in impaired homeostasis

TGFβ1 has been implicated in regulating functional aspects of several distinct immune cell populations including central nervous system (CNS) resident microglia. Activation and priming of microglia have been demonstrated to contribute to the progression of neurodegenerative diseases and, thus, under...

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Detalles Bibliográficos
Autores principales: Zöller, Tanja, Schneider, Artur, Kleimeyer, Christian, Masuda, Takahiro, Potru, Phani Sankar, Pfeifer, Dietmar, Blank, Thomas, Prinz, Marco, Spittau, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167353/
https://www.ncbi.nlm.nih.gov/pubmed/30275444
http://dx.doi.org/10.1038/s41467-018-06224-y