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Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
Hypertrophic cardiomyopathies (HCM) result from distinct single-point mutations in sarcomeric proteins that lead to muscle hypercontractility. While different models account for a pathological increase in the power output, clear understanding of the molecular basis of dysfunction in HCM is the manda...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167380/ https://www.ncbi.nlm.nih.gov/pubmed/30275503 http://dx.doi.org/10.1038/s41467-018-06191-4 |