Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice

Nano-antibodies possess great potential in many applications. However, they are naturally derived from heavy chain-only antibodies (HcAbs), which lack light chains and the CH1 domain, and are only found in camelids and sharks. In this study, we investigated whether the precise genetic removal of the...

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Detalles Bibliográficos
Autores principales: Zhang, Tianyi, Cheng, Xueqian, Yu, Di, Lin, Fuyu, Hou, Ning, Cheng, Xuan, Hao, Shanshan, Wei, Jingjing, Ma, Li, Fu, Yanbin, Ma, Yonghe, Ren, Liming, Han, Haitang, Yu, Shuyang, Yang, Xiao, Zhao, Yaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167435/
https://www.ncbi.nlm.nih.gov/pubmed/30319646
http://dx.doi.org/10.3389/fimmu.2018.02202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167435/
https://www.ncbi.nlm.nih.gov/pubmed/30319646
http://dx.doi.org/10.3389/fimmu.2018.02202

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