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Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice
Nano-antibodies possess great potential in many applications. However, they are naturally derived from heavy chain-only antibodies (HcAbs), which lack light chains and the CH1 domain, and are only found in camelids and sharks. In this study, we investigated whether the precise genetic removal of the...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167435/ https://www.ncbi.nlm.nih.gov/pubmed/30319646 http://dx.doi.org/10.3389/fimmu.2018.02202 |