Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality

PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigate its physiological relevance. Pich KO mice lose viability...

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Detalles Bibliográficos
Autores principales: Albers, Eliene, Sbroggiò, Mauro, Pladevall-Morera, David, Bizard, Anna H., Avram, Alexandra, Gonzalez, Patricia, Martin-Gonzalez, Javier, Hickson, Ian D., Lopez-Contreras, Andres J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167640/
https://www.ncbi.nlm.nih.gov/pubmed/30232008
http://dx.doi.org/10.1016/j.celrep.2018.08.071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167640/
https://www.ncbi.nlm.nih.gov/pubmed/30232008
http://dx.doi.org/10.1016/j.celrep.2018.08.071

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