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Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigate its physiological relevance. Pich KO mice lose viability...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167640/ https://www.ncbi.nlm.nih.gov/pubmed/30232008 http://dx.doi.org/10.1016/j.celrep.2018.08.071 |