Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration

BACKGROUND: Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroendocrine tumors (PNETs). mTOR inhibitors have been used in attempts to treat thes...

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Detalles Bibliográficos
Autores principales: Razmara, Masoud, Monazzam, Azita, Skogseid, Britt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167842/
https://www.ncbi.nlm.nih.gov/pubmed/30285764
http://dx.doi.org/10.1186/s12964-018-0278-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167842/
https://www.ncbi.nlm.nih.gov/pubmed/30285764
http://dx.doi.org/10.1186/s12964-018-0278-2

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