GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy

Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a mass spectrometry–based kinase-trap assay and...

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Detalles Bibliográficos
Autores principales: Aweida, Dina, Rudesky, Inga, Volodin, Alexandra, Shimko, Eitan, Cohen, Shenhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168250/
https://www.ncbi.nlm.nih.gov/pubmed/30061109
http://dx.doi.org/10.1083/jcb.201802018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168250/
https://www.ncbi.nlm.nih.gov/pubmed/30061109
http://dx.doi.org/10.1083/jcb.201802018

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