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GSK3-β promotes calpain-1–mediated desmin filament depolymerization and myofibril loss in atrophy
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a mass spectrometry–based kinase-trap assay and...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168250/ https://www.ncbi.nlm.nih.gov/pubmed/30061109 http://dx.doi.org/10.1083/jcb.201802018 |