Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1

Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug target for epilepsy and neuropathic pain; thus the TSP–α2δ-1 interaction is implicated in both synaptic development and dis...

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Detalles Bibliográficos
Autores principales: Risher, W. Christopher, Kim, Namsoo, Koh, Sehwon, Choi, Ji-Eun, Mitev, Petar, Spence, Erin F., Pilaz, Louis-Jan, Wang, Dongqing, Feng, Guoping, Silver, Debra L., Soderling, Scott H., Yin, Henry H., Eroglu, Cagla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168259/
https://www.ncbi.nlm.nih.gov/pubmed/30054448
http://dx.doi.org/10.1083/jcb.201802057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168259/
https://www.ncbi.nlm.nih.gov/pubmed/30054448
http://dx.doi.org/10.1083/jcb.201802057

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