Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinfl...

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Detalles Bibliográficos
Autores principales: Newman, Laura E., Shadel, Gerald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168260/
https://www.ncbi.nlm.nih.gov/pubmed/30154188
http://dx.doi.org/10.1083/jcb.201808118
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author Newman, Laura E.
Shadel, Gerald S.
author_facet Newman, Laura E.
Shadel, Gerald S.
author_sort Newman, Laura E.
collection PubMed
description What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease.
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spelling pubmed-61682602019-04-01 Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration Newman, Laura E. Shadel, Gerald S. J Cell Biol Commentaries What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease. Rockefeller University Press 2018-10-01 /pmc/articles/PMC6168260/ /pubmed/30154188 http://dx.doi.org/10.1083/jcb.201808118 Text en © 2018 Newman and Shadel http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Newman, Laura E.
Shadel, Gerald S.
Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title_full Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title_fullStr Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title_full_unstemmed Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title_short Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
title_sort pink1/parkin link inflammation, mitochondrial stress, and neurodegeneration
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168260/
https://www.ncbi.nlm.nih.gov/pubmed/30154188
http://dx.doi.org/10.1083/jcb.201808118
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