Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism

Robust kinetochore–microtubule (kMT) attachment is critical for accurate chromosome segregation. G2/M-specific depletion of human Cdt1 that localizes to kinetochores in an Ndc80 complex–dependent manner leads to abnormal kMT attachments and mitotic arrest. This indicates an independent mitotic role...

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Detalles Bibliográficos
Autores principales: Agarwal, Shivangi, Smith, Kyle Paul, Zhou, Yizhuo, Suzuki, Aussie, McKenney, Richard J., Varma, Dileep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168275/
https://www.ncbi.nlm.nih.gov/pubmed/30154187
http://dx.doi.org/10.1083/jcb.201705127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168275/
https://www.ncbi.nlm.nih.gov/pubmed/30154187
http://dx.doi.org/10.1083/jcb.201705127

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