Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan in budding yeas...

Descripción completa

Detalles Bibliográficos
Autores principales: Cruz, Cristina, Della Rosa, Monica, Krueger, Christel, Gao, Qian, Horkai, Dorottya, King, Michelle, Field, Lucy, Houseley, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168286/
https://www.ncbi.nlm.nih.gov/pubmed/30274593
http://dx.doi.org/10.7554/eLife.34081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168286/
https://www.ncbi.nlm.nih.gov/pubmed/30274593
http://dx.doi.org/10.7554/eLife.34081

Ejemplares similares