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Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan in budding yeas...
Autores principales: | Cruz, Cristina, Della Rosa, Monica, Krueger, Christel, Gao, Qian, Horkai, Dorottya, King, Michelle, Field, Lucy, Houseley, Jonathan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168286/ https://www.ncbi.nlm.nih.gov/pubmed/30274593 http://dx.doi.org/10.7554/eLife.34081 |
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