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Mononuclear cell transcriptome changes associated with dimethyl fumarate in MS

OBJECTIVE: To identify short-term changes in gene expression in peripheral blood mononuclear cells (PBMCs) associated with treatment response to dimethyl fumarate (DMF, Tecfidera) in patients with relapsing-remitting MS (RRMS). METHODS: Blood samples were collected from 24 patients with RRMS (median...

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Detalles Bibliográficos
Autores principales: Gafson, Arie R., Kim, Kicheol, Cencioni, Maria T., van Hecke, Wim, Nicholas, Richard, Baranzini, Sergio E., Matthews, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168332/
https://www.ncbi.nlm.nih.gov/pubmed/30283812
http://dx.doi.org/10.1212/NXI.0000000000000470