FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome

Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma (SCLL) syndrome, accompanied by widespread dysregulation of gene activity. We now show that FGFR1 activation is associated with upregulation...

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Detalles Bibliográficos
Autores principales: Hu, Tianxiang, Wu, Qing, Chong, Yating, Qin, Haiyan, Poole, Candace J., van Riggelen, Jan, Ren, Mingqiang, Cowell, John K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168426/
https://www.ncbi.nlm.nih.gov/pubmed/29720732
http://dx.doi.org/10.1038/s41375-018-0124-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168426/
https://www.ncbi.nlm.nih.gov/pubmed/29720732
http://dx.doi.org/10.1038/s41375-018-0124-y

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