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FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome
Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma (SCLL) syndrome, accompanied by widespread dysregulation of gene activity. We now show that FGFR1 activation is associated with upregulation...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168426/ https://www.ncbi.nlm.nih.gov/pubmed/29720732 http://dx.doi.org/10.1038/s41375-018-0124-y |