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Activating and sustaining c-Myc by depletion of miR-144/451 gene locus contributes to B-lymphomagenesis
Hyper activity of protooncogene c-Myc is one of the hallmarks of highly aggressive lymphomas. However, the mechanism of how c-Myc is subjected to activation and amplification is still not well defined. In this study, we use gene knockout strategy to show that targeted depletion of a well-conserved m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168470/ https://www.ncbi.nlm.nih.gov/pubmed/29284789 http://dx.doi.org/10.1038/s41388-017-0055-5 |