Activating and sustaining c-Myc by depletion of miR-144/451 gene locus contributes to B-lymphomagenesis

Hyper activity of protooncogene c-Myc is one of the hallmarks of highly aggressive lymphomas. However, the mechanism of how c-Myc is subjected to activation and amplification is still not well defined. In this study, we use gene knockout strategy to show that targeted depletion of a well-conserved m...

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Detalles Bibliográficos
Autores principales: Ding, Lan, Zhang, Yanqing, Han, Lingling, Fu, Lei, Mei, Xia, Wang, Jijun, Itkow, Jacobi, Elabid, Afaf Elabid Ibrahim, Pang, Lei, Yu, Duonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168470/
https://www.ncbi.nlm.nih.gov/pubmed/29284789
http://dx.doi.org/10.1038/s41388-017-0055-5

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