Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins

Plasmodium parasites exerted a strong selective pressure on primate genomes and mutations in genes encoding erythrocyte cytoskeleton proteins (ECP) determine protective effects against Plasmodium infection/pathogenesis. We thus hypothesized that ECP-encoding genes have evolved in response to Plasmod...

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Detalles Bibliográficos
Autores principales: Sironi, Manuela, Forni, Diego, Clerici, Mario, Cagliani, Rachele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168477/
https://www.ncbi.nlm.nih.gov/pubmed/30279439
http://dx.doi.org/10.1038/s41598-018-33049-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168477/
https://www.ncbi.nlm.nih.gov/pubmed/30279439
http://dx.doi.org/10.1038/s41598-018-33049-y

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