An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice

The increase in the prevalence of antibiotic-resistant bacteria has become a major public health concern. Antimicrobial peptides (AMPs) are emerging as promising candidates addressing this issue. In this study, we designed several AMPs by increasing α-helical contents and positive charges and optimi...

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Detalles Bibliográficos
Autores principales: Yang, Chin-Hao, Chen, Yi-Cheng, Peng, Shih-Yi, Tsai, Andy Po-Yi, Lee, Tony Jer-Fu, Yen, Jui-Hung, Liou, Je-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168480/
https://www.ncbi.nlm.nih.gov/pubmed/30279591
http://dx.doi.org/10.1038/s41598-018-32981-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168480/
https://www.ncbi.nlm.nih.gov/pubmed/30279591
http://dx.doi.org/10.1038/s41598-018-32981-3

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