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Cationic domains in particle-forming and assembly-deficient HBV core antigens capture mammalian RNA that stimulates Th1-biased antibody responses by DNA vaccination

The HBV core protein self-assembles into particles and encapsidates immune-stimulatory bacterial RNA through a cationic COOH-terminal (C150–183) domain. To investigate if different cationic domains have an impact on the endogenous RNA-binding of HBV-C antigens in mammalian cells, we developed a stre...

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Detalles Bibliográficos
Autores principales: Krieger, Jana, Stifter, Katja, Riedl, Petra, Schirmbeck, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168482/
https://www.ncbi.nlm.nih.gov/pubmed/30279478
http://dx.doi.org/10.1038/s41598-018-32971-5