Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration

LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug development. Therefore, we explored the potential role of EDN1 (endothelin) in LAM. We re...

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Detalles Bibliográficos
Autores principales: Chebib, Nader, Archer, Fabienne, Bobet-Erny, Alexandra, Leroux, Caroline, Cottin, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168484/
https://www.ncbi.nlm.nih.gov/pubmed/30279475
http://dx.doi.org/10.1038/s41598-018-32795-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168484/
https://www.ncbi.nlm.nih.gov/pubmed/30279475
http://dx.doi.org/10.1038/s41598-018-32795-3

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