Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

The tissue inhibitor of metalloproteinases-3 (TIMP-3) is a major regulator of extracellular matrix turnover and protein shedding by inhibiting different classes of metalloproteinases, including disintegrin metalloproteinases (ADAMs). Tissue bioavailability of TIMP-3 is regulated by the endocytic rec...

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Detalles Bibliográficos
Autores principales: Scilabra, Simone D., Pigoni, Martina, Pravatá, Veronica, Schätzl, Tobias, Müller, Stephan A., Troeberg, Linda, Lichtenthaler, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168507/
https://www.ncbi.nlm.nih.gov/pubmed/30279425
http://dx.doi.org/10.1038/s41598-018-32910-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168507/
https://www.ncbi.nlm.nih.gov/pubmed/30279425
http://dx.doi.org/10.1038/s41598-018-32910-4

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