Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes show blunted chemotactic responses to arteriogenic s...

Descripción completa

Detalles Bibliográficos
Autores principales: Dorenkamp, Marc, Müller, Jörg P., Shanmuganathan, Kallipatti Sanjith, Schulten, Henny, Müller, Nicolle, Löffler, Ivonne, Müller, Ulrich A., Wolf, Gunter, Böhmer, Frank-D., Godfrey, Rinesh, Waltenberger, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168515/
https://www.ncbi.nlm.nih.gov/pubmed/30279491
http://dx.doi.org/10.1038/s41598-018-33014-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168515/
https://www.ncbi.nlm.nih.gov/pubmed/30279491
http://dx.doi.org/10.1038/s41598-018-33014-9

Ejemplares similares