Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators

In view of the role of sEH (soluble epoxide hydrolase) in hypertension, we have developed a rigorously validated pharmacophore model containing one HBA (Hydrogen Bond Acceptor), two HY (Hydrophobic) and one RA (Ring Aromatic) features. The model was used as a query to search the NCI (National Cancer...

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Detalles Bibliográficos
Autores principales: Tripathi, Neetika, Paliwal, Sarvesh, Sharma, Swapnil, Verma, Kanika, Gururani, Ritika, Tiwari, Akanksha, Verma, Amrita, Chauhan, Monika, Singh, Aarti, Kumar, Dipak, Pant, Aditya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168526/
https://www.ncbi.nlm.nih.gov/pubmed/30279487
http://dx.doi.org/10.1038/s41598-018-32449-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168526/
https://www.ncbi.nlm.nih.gov/pubmed/30279487
http://dx.doi.org/10.1038/s41598-018-32449-4

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