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Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

Female meiotic divisions are extremely asymmetric, producing large oocytes and small polar bodies (PBs). In mouse oocytes, the spindle relocates to the cortex before anaphase of meiosis I (MI). It is presumed that by displacing the future midzone, pre-anaphase spindle repositioning alone ensures asy...

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Detalles Bibliográficos
Autores principales: Wei, Zhe, Greaney, Jessica, Zhou, Chenxi, A. Homer, Hayden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168559/
https://www.ncbi.nlm.nih.gov/pubmed/30279413
http://dx.doi.org/10.1038/s41467-018-06510-9