Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

S. cerevisiae Hal3 (ScHal3) is a moonlighting protein that, is in its monomeric state, regulates the Ser/Thr protein phosphatase Ppz1, but also joins ScCab3 (and in some instances the Hal3 paralog Vhs3) to form an unusual heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme. PPCDC...

Descripción completa

Detalles Bibliográficos
Autores principales: Santolaria, Carlos, Velázquez, Diego, Strauss, Erick, Ariño, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168597/
https://www.ncbi.nlm.nih.gov/pubmed/30279472
http://dx.doi.org/10.1038/s41598-018-32979-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168597/
https://www.ncbi.nlm.nih.gov/pubmed/30279472
http://dx.doi.org/10.1038/s41598-018-32979-x

Ejemplares similares