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Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

Regulation of transcription, replication, and cell division relies on differential protein binding to DNA and chromatin, yet it is unclear which regulatory components remain bound to compacted mitotic chromosomes. By utilizing the buoyant density of DNA–protein complexes after cross-linking, we here...

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Detalles Bibliográficos
Autores principales: Ginno, Paul Adrian, Burger, Lukas, Seebacher, Jan, Iesmantavicius, Vytautas, Schübeler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168604/
https://www.ncbi.nlm.nih.gov/pubmed/30279501
http://dx.doi.org/10.1038/s41467-018-06007-5