Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8(+) T cells for adoptive immunotherapy

Adoptive T cell therapy has shown clinical potential for patients with cancer, though effective treatment is dependent on longevity and potency of the exploited tumor-reactive T cells. Previously, we showed that ex vivo inhibition of AKT using the research compound Akt-inhibitor VIII retained differ...

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Detalles Bibliográficos
Autores principales: Mousset, Charlotte M., Hobo, Willemijn, Ji, Yun, Fredrix, Hanny, De Giorgi, Valeria, Allison, Robert D., Kester, Michel G. D., Falkenburg, J. H. Frederik, Schaap, Nicolaas P. M., Jansen, Joop H., Gattinoni, Luca, Dolstra, Harry, van der Waart, Anniek B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169586/
https://www.ncbi.nlm.nih.gov/pubmed/30288356
http://dx.doi.org/10.1080/2162402X.2018.1488565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169586/
https://www.ncbi.nlm.nih.gov/pubmed/30288356
http://dx.doi.org/10.1080/2162402X.2018.1488565

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