The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described to impair cellular proliferation. The current study reveals that RPL10 R98S cells accumulate reactive oxygen species which promotes mitochon...

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Detalles Bibliográficos
Autores principales: Kampen, Kim R., Sulima, Sergey O., Verbelen, Benno, Girardi, Tiziana, Vereecke, Stijn, Rinaldi, Gianmarco, Verbeeck, Jelle, de Beeck, Joyce Op, Uyttebroeck, Anne, Meijerink, Jules P. P., Moorman, Anthony V., Harrison, Christine J., Spincemaille, Pieter, Cools, Jan, Cassiman, David, Fendt, Sarah-Maria, Vermeersch, Pieter, De Keersmaecker, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169730/
https://www.ncbi.nlm.nih.gov/pubmed/29930300
http://dx.doi.org/10.1038/s41375-018-0176-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169730/
https://www.ncbi.nlm.nih.gov/pubmed/29930300
http://dx.doi.org/10.1038/s41375-018-0176-z

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