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Whole-exome sequencing capture kit biases yield false negative mutation calls in TCGA cohorts

The Cancer Genome Atlas (TCGA) provides a genetic characterization of more than ten thousand tumors, enabling the discovery of novel driver mutations, molecular subtypes, and enticing drug targets across many histologies. Here we investigated why some mutations are common in particular cancer types...

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Detalles Bibliográficos
Autores principales:	Wang, Victor G., Kim, Hyunsoo, Chuang, Jeffrey H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169918/ https://www.ncbi.nlm.nih.gov/pubmed/30281678 http://dx.doi.org/10.1371/journal.pone.0204912

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