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Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K(+) channel
Membrane potential regulates the activity of voltage-dependent ion channels via specialized voltage-sensing modules but the mechanisms involved in coupling voltage-sensor movement to pore opening remain unclear due to lack of resting state structures and robust methods to identify allosteric pathway...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170002/ https://www.ncbi.nlm.nih.gov/pubmed/29581567 http://dx.doi.org/10.1038/s41594-018-0047-3 |