Sub-ångstrom cryo-EM structure of a prion protofibril reveals a polar clasp

The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method, MicroED, we reveal the sub-1Å resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. Th...

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Detalles Bibliográficos
Autores principales: Gallagher-Jones, Marcus, Glynn, Calina, Boyer, David R., Martynowycz, Michael W., Hernandez, Evelyn, Miao, Jennifer, Zee, Chih-Te, Novikova, Irina V., Goldschmidt, Lukasz, McFarlane, Heather T., Helguera, Gustavo F., Evans, James E., Sawaya, Michael R., Cascio, Duilio, Eisenberg, David, Gonen, Tamir, Rodriguez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170007/
https://www.ncbi.nlm.nih.gov/pubmed/29335561
http://dx.doi.org/10.1038/s41594-017-0018-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170007/
https://www.ncbi.nlm.nih.gov/pubmed/29335561
http://dx.doi.org/10.1038/s41594-017-0018-0

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