Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity

A number of autoimmunity-associated MHC class II proteins interact only weakly with the invariant chain–derived class II–associated invariant chain peptide (CLIP). CLIP dissociates rapidly from I-A(g7) even in the absence of DM, and this property is related to the type 1 diabetes–associated β57 poly...

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Detalles Bibliográficos
Autores principales: Ito, Yoshinaga, Ashenberg, Orr, Pyrdol, Jason, Luoma, Adrienne M., Rozenblatt-Rosen, Orit, Hofree, Matan, Christian, Elena, Ferrari de Andrade, Lucas, Tay, Rong En, Teyton, Luc, Regev, Aviv, Dougan, Stephanie K., Wucherpfennig, Kai W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170167/
https://www.ncbi.nlm.nih.gov/pubmed/30185635
http://dx.doi.org/10.1084/jem.20180300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170167/
https://www.ncbi.nlm.nih.gov/pubmed/30185635
http://dx.doi.org/10.1084/jem.20180300

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