Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. To better understand the impact of B cells in this disease, we gen...

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Detalles Bibliográficos
Autores principales: Wray-Dutra, Michelle N., Al Qureshah, Fahd, Metzler, Genita, Oukka, Mohamed, James, Richard G., Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170176/
https://www.ncbi.nlm.nih.gov/pubmed/30194267
http://dx.doi.org/10.1084/jem.20180617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170176/
https://www.ncbi.nlm.nih.gov/pubmed/30194267
http://dx.doi.org/10.1084/jem.20180617

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