High-dimensional single cell analysis identifies stem-like cytotoxic CD8(+) T cells infiltrating human tumors

CD8(+) T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8(+) T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors c...

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Detalles Bibliográficos
Autores principales: Brummelman, Jolanda, Mazza, Emilia M.C., Alvisi, Giorgia, Colombo, Federico S., Grilli, Andrea, Mikulak, Joanna, Mavilio, Domenico, Alloisio, Marco, Ferrari, Francesco, Lopci, Egesta, Novellis, Pierluigi, Veronesi, Giulia, Lugli, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170179/
https://www.ncbi.nlm.nih.gov/pubmed/30154266
http://dx.doi.org/10.1084/jem.20180684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170179/
https://www.ncbi.nlm.nih.gov/pubmed/30154266
http://dx.doi.org/10.1084/jem.20180684

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