Cargando…

High-dimensional single cell analysis identifies stem-like cytotoxic CD8(+) T cells infiltrating human tumors

CD8(+) T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8(+) T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brummelman, Jolanda, Mazza, Emilia M.C., Alvisi, Giorgia, Colombo, Federico S., Grilli, Andrea, Mikulak, Joanna, Mavilio, Domenico, Alloisio, Marco, Ferrari, Francesco, Lopci, Egesta, Novellis, Pierluigi, Veronesi, Giulia, Lugli, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170179/ https://www.ncbi.nlm.nih.gov/pubmed/30154266 http://dx.doi.org/10.1084/jem.20180684

Ejemplares similares

Background fluorescence and spreading error are major contributors of variability in high‐dimensional flow cytometry data visualization by t‐distributed stochastic neighboring embedding
por: Mazza, Emilia Maria Cristina, et al.
Publicado: (2018)

Single-cell profiling defines the prognostic benefit of CD39(high) tissue resident memory CD8+ T cells in luminal-like breast cancer
por: Losurdo, Agnese, et al.
Publicado: (2021)

Author Correction: Single-cell profiling defines the prognostic benefit of CD39(high) tissue resident memory CD8+ T cells in luminal-like breast cancer
por: Losurdo, Agnese, et al.
Publicado: (2021)

Are human Vδ2(pos) T cells really resistant to aging and Human Cytomegalovirus infection?()
por: Mikulak, Joanna, et al.
Publicado: (2019)

On the Way to Become a Natural Killer Cell
por: Di Vito, Clara, et al.
Publicado: (2019)

Immunotherapy Monitoring with Immune Checkpoint Inhibitors Based on [(18)F]FDG PET/CT in Metastatic Melanomas and Lung Cancer
por: Lopci, Egesta
Publicado: (2021)

Meditating on Cancer Management at the Time of Immunotherapy
por: Lopci, Egesta
Publicado: (2022)

Subpopulations of Circulating Cells with Morphological Features of Malignancy Are Preoperatively Detected and Have Differential Prognostic Significance in Non-Small Cell Lung Cancer
por: Fina, Emanuela, et al.
Publicado: (2021)

NKG2A Immune Checkpoint in Vδ2 T Cells: Emerging Application in Cancer Immunotherapy
por: Cazzetta, Valentina, et al.
Publicado: (2023)

Hepatic Natural Killer Cells: Organ-Specific Sentinels of Liver Immune Homeostasis and Physiopathology
por: Mikulak, Joanna, et al.
Publicado: (2019)

Metabolic Imaging in B-Cell Lymphomas during CAR-T Cell Therapy
por: Linguanti, Flavia, et al.
Publicado: (2022)

NK Cell Subset Redistribution during the Course of Viral Infections
por: Lugli, Enrico, et al.
Publicado: (2014)

Advances in Lung Cancer Imaging and Therapy
por: Lopci, Egesta, et al.
Publicado: (2021)

Editorial: Response assessment of radioligand therapies
por: Lopci, Egesta, et al.
Publicado: (2022)

Natural Killer–Dendritic Cell Interactions in Liver Cancer: Implications for Immunotherapy
por: Cazzetta, Valentina, et al.
Publicado: (2021)

Impact of Antibiotic Therapy and Metabolic Parameters in Non-Small Cell Lung Cancer Patients Receiving Checkpoint Inhibitors
por: Castello, Angelo, et al.
Publicado: (2021)

Host Immune Responses in HIV-1 Infection: The Emerging Pathogenic Role of Siglecs and Their Clinical Correlates
por: Mikulak, Joanna, et al.
Publicado: (2017)

Inhibiting the inhibitors: Checkpoints blockade in solid tumors
por: Mavilio, Domenico, et al.
Publicado: (2013)

18F-FDG PET/CT in Restaging and Evaluation of Response to Therapy in Lung Cancer: State of the Art
por: Castello, Angelo, et al.
Publicado: (2020)

Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells
por: Polidoro, Michela Anna, et al.
Publicado: (2020)

Surgical and Oncological Outcomes of En-Bloc Resection for Malignancies Invading the Thoracic Spine
por: Novellis, Pierluigi, et al.
Publicado: (2022)

Overview of the outcomes of robotic segmentectomy and lobectomy
por: Veronesi, Giulia, et al.
Publicado: (2021)

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells
por: Hudspeth, Kelly, et al.
Publicado: (2013)

FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression
por: Vitali, Eleonora, et al.
Publicado: (2017)

Quality of Life, Postoperative Pain, and Lymph Node Dissection in a Robotic Approach Compared to VATS and OPEN for Early Stage Lung Cancer
por: Novellis, Pierluigi, et al.
Publicado: (2021)

Comparison of Metabolic and Morphological Response Criteria for Early Prediction of Response and Survival in NSCLC Patients Treated With Anti-PD-1/PD-L1
por: Castello, Angelo, et al.
Publicado: (2020)

Novel multifunctional antibody approved for the treatment of breast cancer
por: Mavilio, Domenico, et al.
Publicado: (2013)

Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic Implications
por: Di Vito, Clara, et al.
Publicado: (2022)

Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
por: De Biasi, Sara, et al.
Publicado: (2021)

CRUSTY: a versatile web platform for the rapid analysis and visualization of high-dimensional flow cytometry data
por: Puccio, Simone, et al.
Publicado: (2023)

Circulating Tumor Cells and Metabolic Parameters in NSCLC Patients Treated with Checkpoint Inhibitors
por: Castello, Angelo, et al.
Publicado: (2020)

Single-cell profiling reveals the dynamics of cytomegalovirus-specific T cells in haploidentical hematopoietic stem cell transplantation
por: van Beek, Jasper J. P., et al.
Publicado: (2021)

Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas
por: Carenza, Claudia, et al.
Publicado: (2023)

Soluble PD-L1 in NSCLC Patients Treated with Checkpoint Inhibitors and Its Correlation with Metabolic Parameters
por: Castello, Angelo, et al.
Publicado: (2020)

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2(pos) T cells in elderly patients affected by liver metastatic colorectal cancer
por: Bruni, Elena, et al.
Publicado: (2019)

Prolonged air leak after robotic lung resection: a narrative review
por: Muriana, Piergiorgio, et al.
Publicado: (2022)

Perioperative Outcome of Robotic Approach Versus Manual Videothoracoscopic Major Resection in Patients Affected by Early Lung Cancer: Results of a Randomized Multicentric Study (ROMAN Study)
por: Veronesi, Giulia, et al.
Publicado: (2021)

Engagement of Siglec-7 Receptor Induces a Pro-Inflammatory Response Selectively in Monocytes
por: Varchetta, Stefania, et al.
Publicado: (2012)

Metabolism of Stem and Progenitor Cells: Proper Methods to Answer Specific Questions
por: Martano, Giuseppe, et al.
Publicado: (2019)

The Role of Radiomics in the Era of Immune Checkpoint Inhibitors: A New Protagonist in the Jungle of Response Criteria
por: Castello, Angelo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qhs00e21kij78ngevv1kmjlbkg