Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA

To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and cell cycle regulators were observed in p27 (IΔ)...

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Detalles Bibliográficos
Autores principales: Choi, Jun Young, Yun, Woo Bin, Kim, Ji Eun, Lee, Mi Rim, Park, Jin Ju, Song, Bo Ram, Kim, Hye Ryeong, Park, Ji Won, Kang, Mi Ju, Kang, Byeong Cheol, Lee, Han-Woong, Hwang, Dae Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170220/
https://www.ncbi.nlm.nih.gov/pubmed/30310408
http://dx.doi.org/10.5625/lar.2018.34.3.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170220/
https://www.ncbi.nlm.nih.gov/pubmed/30310408
http://dx.doi.org/10.5625/lar.2018.34.3.118

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