Cargando…

Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA

To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and cell cycle regulators were observed in p27 (IΔ)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Jun Young, Yun, Woo Bin, Kim, Ji Eun, Lee, Mi Rim, Park, Jin Ju, Song, Bo Ram, Kim, Hye Ryeong, Park, Ji Won, Kang, Mi Ju, Kang, Byeong Cheol, Lee, Han-Woong, Hwang, Dae Youn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Association for Laboratory Animal Science 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170220/ https://www.ncbi.nlm.nih.gov/pubmed/30310408 http://dx.doi.org/10.5625/lar.2018.34.3.118

Ejemplares similares

Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment
por: Kang, Mi Ju, et al.
Publicado: (2020)

Correction to: Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment
por: Kang, Mi Ju, et al.
Publicado: (2020)

Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice
por: Park, Hyeong Ju, et al.
Publicado: (2022)

Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis
por: Goldstein, Jill, et al.
Publicado: (2015)

Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis
por: Winter, Markus, et al.
Publicado: (2016)

Morusin Functions as a Lipogenesis Inhibitor as Well as a Lipolysis Stimulator in Differentiated 3T3-L1 and Primary Adipocytes
por: Lee, Mi Rim, et al.
Publicado: (2018)

T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development
por: Vähätupa, Maria, et al.
Publicado: (2016)

Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
por: Kim, Ji Eun, et al.
Publicado: (2018)

Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice
por: Park, Jin Ju, et al.
Publicado: (2020)

Dose dependence and durability of the therapeutic effects of Asparagus cochinchinensis fermented extract in an ovalbumin-challenged asthma model
por: Choi, Jun Young, et al.
Publicado: (2018)

Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: (1)H NMR Metabolomic and Biochemical Study
por: Sati, Jasmine, et al.
Publicado: (2016)

Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis
por: Kong, Ying-Hui, et al.
Publicado: (2018)

Chemopreventive Effects of Oral Pterostilbene in Multistage Carcinogenesis of Skin Squamous Cell Carcinoma Mouse Model Induced by DMBA/TPA
por: Surien, Omchit, et al.
Publicado: (2022)

Sex differences in coronary angiographic findings in patients with stable chest pain: analysis of data from the KoRean wOmen’S chest pain rEgistry (KoROSE)
por: Kim, Hack-Lyoung, et al.
Publicado: (2022)

Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice
por: Fu, Wen, et al.
Publicado: (2009)

Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103(+)DC cells
por: Zeng, Fan‐lian, et al.
Publicado: (2023)

Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-κB-dependent MMP-9 expression in MCF-7 breast cancer cells
por: Kim, Ha-Rim, et al.
Publicado: (2014)

miRGen: a database for the study of animal microRNA genomic organization and function
por: Megraw, Molly, et al.
Publicado: (2007)

miRGen 2.0: a database of microRNA genomic information and regulation
por: Alexiou, Panagiotis, et al.
Publicado: (2010)

Anti-obesity effect in high-fat-diet-induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris
por: Lee, Mi Rim, et al.
Publicado: (2019)

Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells
por: Lee, Young-Rae, et al.
Publicado: (2013)

Effects of multiparity on left ventricular diastolic dysfunction in women: cross-sectional study of the KoRean wOmen’S chest pain rEgistry (KoROSE)
por: Kim, Hyun-Jin, et al.
Publicado: (2018)

Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice
por: Yun, Woo Bin, et al.
Publicado: (2021)

Lipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats
por: Lee, Mi Rim, et al.
Publicado: (2017)

Suppression of TPA-induced cancer cell invasion by Peucedanum japonicum Thunb. extract through the inhibition of PKCα/NF-κB-dependent MMP-9 expression in MCF-7 cells
por: KIM, JEONG-MI, et al.
Publicado: (2016)

Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris
por: Lee, Mi Rim, et al.
Publicado: (2018)

K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors
por: Tago, Kenji, et al.
Publicado: (2021)

Constipation in Tg2576 mice model for Alzheimer’s disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response
por: Kim, Ji Eun, et al.
Publicado: (2019)

DIANA-miRGen v3.0: accurate characterization of microRNA promoters and their regulators
por: Georgakilas, Georgios, et al.
Publicado: (2016)

RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors
por: Kuzin, Alexander, et al.
Publicado: (2021)

A Case of Atypical Adenomatous Hyperplasia of Larger Than 2 cm
por: Park, Bo Mi, et al.
Publicado: (2013)

New Sesquiterpene Glycosides from the Flowers of Aster koraiensis and Their Inhibition Activities on EGF- and TPA-Induced Cell Transformation
por: Seo, Young-Hye, et al.
Publicado: (2023)

Intra-Arterial Thrombolysis after Full-Dose Intravenous tPA via the "Drip and Ship" Approach in Patients with Acute Ischemic Stroke: Preliminary Report
por: Park, Man-Seok, et al.
Publicado: (2011)

The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model
por: Choi, Jun Young, et al.
Publicado: (2018)

Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study
por: Kim, Jong S., et al.
Publicado: (2019)

Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
por: Choi, Hansol, et al.
Publicado: (2017)

The association between hyperuricemia and cardiovascular disease history: A cross-sectional study using KoGES HEXA data
por: Kim, Joo-Hee, et al.
Publicado: (2022)

Deacetylase activity-independent transcriptional activation by HDAC2 during TPA-induced HL-60 cell differentiation
por: Jung, Hyeonsoo, et al.
Publicado: (2018)

DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs
por: Perdikopanis, Nikos, et al.
Publicado: (2020)

The effect of childbirth on Carcinogenesis of DMBA-induced breast cancer in female SD rats
por: Zhao, Ji-An, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_baqkq5hjcppc91plsarr4t1stg