Nuclear expansion and pore opening are instant signs of neuronal hypoxia and can identify poorly fixed brains

The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal injury. Importantly, these changes can be identified with commonly used nuclear s...

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Detalles Bibliográficos
Autores principales: Dehghani, Anisa, Karatas, Hulya, Can, Alp, Erdemli, Esra, Yemisci, Muge, Eren-Kocak, Emine, Dalkara, Turgay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170374/
https://www.ncbi.nlm.nih.gov/pubmed/30282977
http://dx.doi.org/10.1038/s41598-018-32878-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170374/
https://www.ncbi.nlm.nih.gov/pubmed/30282977
http://dx.doi.org/10.1038/s41598-018-32878-1

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