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Gut Colonization with Methanogenic Archaea Lowers Plasma Trimethylamine N-oxide Concentrations in Apolipoprotein e−/− Mice
A mechanistic link between trimethylamine N-oxide (TMAO) and atherogenesis has been reported. TMAO is generated enzymatically in the liver by the oxidation of trimethylamine (TMA), which is produced from dietary choline, carnitine and betaine by gut bacteria. It is known that certain members of meth...
Autores principales: | Ramezani, Ali, Nolin, Thomas D., Barrows, Ian R., Serrano, Myrna G., Buck, Gregory A., Regunathan-Shenk, Renu, West, Raymond E., Latham, Patricia S., Amdur, Richard, Raj, Dominic S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170401/ https://www.ncbi.nlm.nih.gov/pubmed/30283097 http://dx.doi.org/10.1038/s41598-018-33018-5 |
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