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Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors

Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling. Their upregulation results in various disease conditions, for example, inflammation, hypoxia and cancer. Therefore, efforts have been made to synth...

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Detalles Bibliográficos
Autores principales: Hassan, Sidra, Channar, Pervaiz Ali, Larik, Fayaz Ali, Saeed, Aamer, Shah, Hamid Saeed, Lecka, Joanna, Sévigny, Jean, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170555/
https://www.ncbi.nlm.nih.gov/pubmed/30839737
http://dx.doi.org/10.1098/rsos.180837